EFFECT OF THREE MONTHS TREATMENT WITH UKRAIN ON PERIPHERAL BLOOD MORPHOLOGY IN RODENTS

JAGIEŁŁO-WÓJTOWICZ E.,¹* KLEINROK Z.,¹ MATUSZEK B.,¹ SURMACZYŃSKA B.,¹ BARAN E.,¹ NOWICKY W.,² NOWICKY J.W.²

1) Department of Pharmacology, Medical Academy, Jaczewskiego 8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.

*Author to whom correspondence should be addressed.

Summary: Studies on Albino Swiss mice and Wistar rats have demonstrated that Ukrain administered intraperitoneally (i.p.) for three months produces the following effects in the haematologic parameters: increased leucocytes and decreased thrombocytes. The haemoglobin and erythrocyte levels, as well as haematocrit value, were unchanged. In the leucogram changes were observed; i.e., a fall in the number of neutrophil segments and an increase in the lymphocyte count. The erythrocyte indices, P.C.V., M.C.V., M.C.H, and M.C.H.C. were not changed by a period of three months i.p. Ukrain administration. The observed changes were more marked in female than in male animals and were greater in mice than in rats.