MODIFICATION OF ANTINOCICEPTIVE ACTION OF MORPHINE BY UKRAIN IN RODENTS
JAGIEŁŁO-WÓJTOWICZ E.1*, KLEINROK Z.1, CHODKOWSKA A.1, FELDO M.,1 NOWICKY J.W.2
1) Department of Pharmacology, Medical Academy, Jaczewskiego
8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.
*Author to whom correspondence should be addressed.
Summary: Morphine-induced (0.1 mg/kg s.c.) antinociceptive action was determined in rodents by using the writhing syndrome, hot plate and tail-flick tests. Ukrain given i.p. in doses equivalent to 0.05 and 0.1 LD50 did not affect the reactivity of the mice in the writhing syndrome test. Only in a dose of 0.1 LD50 did Ukrain produce an antinociceptive effect in the hot-plate and tail-flick tests. Ukrain significantly enhanced the antinociceptive effect of morphine in the hot-plate and tail-flick tests. The action of morphine was significantly suppressed by Ukrain in the writhing syndrome test in mice. These results indicated that Ukrain modified the antinociceptive action of morphine.