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BIOLOGICAL PROPERTIES OF UKRAIN IN EXPERIMENTAL AND CLINICAL INVESTIGATIONS

J.W. Nowicky

Ukrainian Anti-Cancer Institute, Vienna, Austria

Abstract The review is dedicated to Ukrain, a semi-synthetic thiophosphoric acid compound of alkaloids isolated from Chelidonium Majus L. (greater celandine). Data is presented on malignotoxic properties of Ukrain both in vitro and in vivo obtained in various countries, universities and research institutes. The Ukrain is shown to have no adverse effect on normal cell cultures at the concentrations toxic to all the cancer cells under study. Besides, the Ukrain revealed some immunomodulating properties as well. Advantages of the Ukrain as compared with well-known cytostatics: Doxorubicin, 5-Fluorouracil and Cisplatin, are shown. The references on clinical use of this drug in over 1000 cancer patients, are presented.

- , (Chelidonium Majus L.).