Comparative Study of the Cytostatic Effects of Oliphen and Ukrain

I. VOLTCHEK¹ - M. KAMYSHENTSEV² - Y. LAVINSKY⁴ - J. NOWICKY⁴ - Y. MEDVEDEV³ - L. LITVINCHUK²

¹ Avalance.
² Institute of Influenza.
³ Research Institute of Highly Pure Biopreparations St. Peterburg, Russia;
⁴ Ukrainian Anti-Cancer institute. Vienna. Austria

Correspondence. lgor V. Voltchek. Avalanche. 14 Izmailovsky pr. 198052 St.Petersburg, Russia. Tel.:+7.812.2726974, Fax: +7.812.2942524.
New address: I.V. Voltchek. M.D., Ph.D., Russian Medical Co. 1 Gagarina Pr., 196105 St. Petersburg, Russia. Tel. +7.812.5425706. Fax: +7.812.5425706.

This paper was presented at the 9th Mediterranean Congress of Chemotherapy, Milan, Italy, June 1994.

Summary

We evaluated the cytostatic effect of the antihypoxic drug Oliphen (Polyoxiarilene) in comparison with the well known cytostatic and immunomodulating agent Ukrain (a semisynthetic compound derived from Chelidonium majus L. alkaloids). We used tumor cell lines M-HeLa and Hep-2/0-6-5, normal cell cultures from human embryo kidney and lung fibroblasts. The cytodestructive effect of Ukrain on both tumor cell lines was more significant at all tested concentrations. Oliphen was cytotoxic only against Hep-2 but not the HeLa cell line. The proliferative activity of both normal cell cultures decreased in the presence of Oliphen and Ukrain concentrations of 0.1 and 0.015% and was stable at 0.0015 and 0.00015%.

Key words: Ukrain, Oliphen, cytostatic, cytotoxic, antitumor.