EFFECT OF UKRAIN ON HUMAN LIVER ALCOHOL DEHYDROGENASE ACTIVITY IN VITRO

JAGIEŁŁO-WÓJTOWICZ E., DUDKA J., DAWIDEK-PIETRYKA K.

Department of Toxicology, University Medical School, Lublin, Poland.

Address for correspondence: E. Jagiełło-Wójtowicz, Department of Toxicology, University Medical School, Chodki 7, 20-093 Lublin, Poland.

Summary: In the present study it was found that Ukrain inhibits the ethanol oxidation process catalyzed by human alcohol dehydrogenase (ADH). Ukrain at a concentration of 10^-6, 2.5 x 10^-6, and 5.0 x 10^-6 Μ decreased liver ADH activity in the presence ethanol (approximately 8.41%, 13.28%, 16.69%, respectively) as well as in the presence of methanol (approximately 13.29%, 19.07% and 42.20%, respectively).