UKRAIN IN THE TREATMENT OF PROSTATE CANCER PATIENTS
Villa Medica Clinic, Edenkoben, Germany.
Address for correspondence: B. Aschhoff, Villa Medica Clinic, Klosterstrasse 179, D-67480 Edenkoben
Summary: Ukrain is a semisynthetic drug with high anticancer activity. A total of 74 patients with different stages of prostate cancer were treated in our clinic during the period from September 1997 to January 2003. In all patients, metastases into bones and lymphatic nodes were present. Ukrain dosage was 0.3 mg/kg body weight three times a week. Regional hyperthermia at 13.56 MHz was delivered to metastatic tumors in bones and lymphatic nodes, leading to the increase of local temperature to more than 42.5 °С. Analgesics were prescribed according to the World Health Organization's (WHO) Analgesie Ladder. Effectiveness of treatment was estimat-ed according to the Standard complex of diagnostic measurements: digital rectal examination, ultrasonography and prostate-specific antigen (PSA) detection. According to the results of treatment, 54 patients (73%) were completely free of cancer. Taking into account the presence of patients with high Gleason scores and the fail-ure of Standard treatment, this exceeds the response rate of all existing methods of prostate cancer treatment.