METABOLIC CONTROL AND TREATMENT OF MALIGNANT GROWTH:
TUMOR DEVELOPMENT, PATTERNS OF AMINO ACID IMBALANCE AND UKRAIN
NEFYODOV L.I.1, DOROSHENKO Y.M.2, SMIRNOV V.Y.2, UGLYANITSA K.N.3, NOWICKY W.4
1) Department of Biochemistry, Yanka Kupala State University of Grodno, Grodno, Belarus.
2) Central Scientific Laboratory, Grodno Medical School, Grodno, Belarus.
3) Department of Oncology, Grodno Medical School, Grodno, Belarus.
4) Ukrainian Anti-Cancer Institute, Vienna, Austria.
Address for correspondence: L.I. Nefyodov, Department of Biochemistry, Yanka Kupala State University of Grodno, ul. Ozheshko 22, 230023 Grodno, Belarus.
Summary: In experimental (W-256, SM-1 and PC-1 tumors) and clinical (breast, bladder and prostate cancers) studies, the use of Ukrain was proven to be safe and highly effective against cancer, inhibiting protein synthesis in cancer cells, selectively accumulating in tumor tissue after a single intravenous administration and controlling cancer-induced metabolic imbalance. Ukrain inhibits metabolic processes in the tumor, causing metabolic disorders in cancer cells and affecting the transport and intermediate metabolism of amino acids involved in the processes of malignant growth. The cancerostatic action of Ukrain is achieved by controlling amino acid pool formation in the host organism and tumor, preventing the active transportation of amino acids into cancer cells and inhibiting some metabolic processes essential for the development of cancer.