ASSESSMENT OF THE FUNCTIONAL STATE AND MORPHOLOGICAL STRUCTURE OF THE LIVER OF RATS AFTER ADMINISTRATION OF THE DRUG UKRAIN
EGOROV A., BELANOVSKAYA E., RUDYAK T., MELNICHENKO N., ZVERINSKY I.
Institute of Biochemistry, Grodno, Belarus.
Address for correspondence: Dr. Igor Zverinsky, Institute of Biochemistry, 230017, BLK-50, Grodno, Belarus.
Summary: We studied the effect of the antitumor drug Ukrain on the function and morphological structure of intact rats. After administration of Ukrain at doses of 1 and 2 mg/kg body weight for 6 days, no significant changes were revealed in albumin and mucopolysaccharide concentration, aminotransferase activity, or thymol test value, or in the morphology of liver tissue, when comparing test and control groups. Administration of Ukrain significantly reduced the serum concentration of middle molecules.