SELECTED CALCIOTROPIC HORMONES IN SERUM OF SEXUALLY MATURE FEMALE RATS TREATED WITH UKRAIN
Department of Orthopedics, Medical University School, Lublin, Poland.
Address for correspondence: M. Jablohski, Department of Orthopedics, Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland.
Summary: Ukrain, an acid alkaloid derivative of Chelidonium majus L, was administered intraperitoneally to sexually mature female rats at doses of 7, 14 and 28 mg/kg every other day for 10 days, followed by a 10-day break. This procedure was performed five times. At the end of the experiment, serum levels of selected cal-ciotropic hormones, i.e. corticosterone, progesterone, parathyroid hormone and calcitonin, were assessed. A decrease of serum corticosterone in relation to controls occurred in rats after administration of the drug at the 28-mg/kg dose. The drug administered did not significantly affect serum level of progesterone in investigated animals. Ukrain administered at a dose of 7 mg/kg caused a significant increase in the serum level of parathyroid hormone. No significant changes in the serum level of calcitonin were observed within the groups investigated.