SERUM LEVELS OF CORTICOSTERONE, PROGESTERONE, PARATHYROID HORMONE AND CALCITONIN IN OVARIECTOMIZED RATS AFTER 3-MONTH TREATMENT WITH UKRAIN
Department of Orthopedics, Medical University School, Lublin, Poland.
Address for correspondence: M. Jablonski, Department of Orthopedics, Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland
Summary: Ukrain was administered intraperitoneally to ovariectomized rats at doses of 7, 14 and 28 mg/kg every other day for 10 days, followed by a 10-day break. This procedure was performed five times. Serum levels of selected calciotropic hormones, i.e., corticosterone, progesterone, parathyroid hormone and calcitonin, were assessed. A decrease of serum corticosterone in relation to controls occurred in serum levels of ovariectomized rats treated with Ukrain 14 mg/kg compared with ovariectomized-only rats. Ovariectomy caused a significant drop in serum levels of progesterone. Ukrain did not significantly affect serum levels of this hormone in the ovariectomized animals investigated. No significant changes in the serum levels of either parathyroid hormone or calcitonin were observed in the groups investigated.