EFFECTS OF UKRAIN IN ACUTE INTOXICATION WITH STREPTOZOTOCIN IN RATS
JAGIELLO-WOJTOWICZ E., KLEINROK A., JUREK D.
Department of Toxicology, the Feliks Skubiszewski Medical University, Lublin, Poland.
Address for correspondence: E. Jagiello-Wojtowicz, Department of Toxicology, the Feliks Skubiszewski Medical University, Chodzki 8 Str, 20-093 Lublin, Poland.
Summary: In this study we investigated the influence of Ukrain, a thiophosphoric acid alkaloid derivative from Chelidonium majus L, on the kidney dysfunction parameters in rats poisoned with streptozotocin (STZ). At 24 h after acute intraperitoneal intoxication with STZ 200 mg/kg, the animals received Ukrain intrperitoneally at doses of 3.5, 7 and 14 mg/kg once a day for 10 days. STZ was found to significantly increase the concentration of creatinine and to decrease the concentration of urea, but it did not affect the concentration of total protein and beta-2-microglobulin in the blood serum compared with the control group. Ukrain administered for 10 days significantly intensified the nephrotoxic effects of STZ and increased the death rate of animals in these groups.