INTERACTION BETWEEN UKRAIN AND AMINOPHENAZONE IN ANALGESIC TESTS IN RODENTS

KLEINROK Z.,¹* JAGIEŁŁO-WÓJTOWICZ E.,¹ NOWICKY J.W.,² CHODKOWSKA A.,¹ FELDO M.¹

1) Department of Pharmacology, Medical Academy, Jaczewskiego 8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.

* Author to whom correspondence should be addressed.

Summary: The effect of Ukrain on the analgesic activity of aminophenazone was studied in mice and rats. Antinociceptive action induced by aminophenazone in doses of 50 or 100mg/kg intraperitoneally (i.p.) was determined by using the writhing syndrome, hot-plate tests and tail-flick latency. The action of aminophenazone was significantly enhanced by Ukrain in the writhing syndrome test and in the tail-flick test. Antinociceptive action of aminophenazone was decreased by Ukrain in the hot-plate test in mice. These results suggest that Ukrain, given simultaneously with aminophenazone, changes susceptibility of animals to nociceptive reaction in the tests performed.