SOME PHARMACOLOGICAL PROPERTIES OF PROLONGED ADMINISTRATION OF UKRAIN IN RODENTS

KLEINROK Z.,¹* JAGIEŁŁO-WÓJTOWICZ E.,¹ NOWICKY J.W.,² CHODKOWSKA A.,¹ FELDO M.,¹ MATUSZEK B.¹

1) Department of Pharmacology, Medical Academy, Jaczewskiego 8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.

*Author to whom correspondence should be addressed.

Summary: Some pharmacological properties of Ukrain administered intraperitoneally (i.p.) once daily for three months in mice and rats of both sexes were studied. A three month treatment with Ukrain significantly depressed the spontaneous locomotor activity and did not affect the motor coordination of mice and rats of both sexes. Ukrain did not affect the body weight gain as well as the mass of internal organs; the exception was an increase in the mass of the spleen in rats. Biochemical studies indicated that a three month treatment with Ukrain depressed the whole brain dopamine (DA) concentrations and did not affect the noradrenaline (NA) concentrations. Long-term administration of Ukrain showed no characteristic changes in the concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the whole brain. The observed changes after three months' treatment with Ukrain are similar in mice and rats of both sexes.