EFFECT OF SINGLE AND PROLONGED ADMINISTRATION OF UKRAIN ON PROLACTIN CONCENTRATION IN RATS

JAGIEŁŁO-WÓJTOWICZ E.,¹* KLEINROK Z.,¹ NOWICKY J.W.,² MATUSZEK B.,¹ BARAN E.,¹ SURMACZYNSKA B.¹

1) Department of Pharmacology, Medical Academy, Jaczewskiego 8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.

*Author to whom correspondence should be addressed.

Summary: The effect of single and prolonged administration of Ukrain on the serum prolactin concentrations in rats of both sexes was investigated. One hour after intraperitoneal (i.p.) administration of Ukrain in rats, in doses of 7, 14 and 28 mg/kg, the drug did not affect their serum prolactin concentration. Only in a dose of 28 mg/kg did this drug decrease serum prolactin in a group of female rats. Repeated i.p. treatment (once daily for three months) with 7, 14 and 28 mg/kg of Ukrain significantly increased the serum prolactin concentration in rats of both sexes. The most marked effect was observed in the group of female rats.