EFFECT OF UKRAIN ON THE EFFICACY OF ANTI-EPILEPTIC DRUGS AGAINST MAXIMAL ELECTROSHOCK-INDUCED SEIZURES IN MICE

JAGIEŁŁO-WÓJTOWICZ E.,¹* KLEINROK Z.,¹ FELDO M.¹, CHODKOWSKA A.,¹ NOWICKY J.W.²

1) Department of Pharmacology, Medical Academy, Jaczewskiego 8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.

* Author to whom correspondence should be addressed.

Summary: It has been found that Ukrain, given intraperitoneally (i.p.), did not influence the threshold for maximal electroconvulsions in mice. Ukrain in doses of 9.5 and 19 mg/kg significantly enhanced the protective efficacy of valproate, decreasing the ED₅₀ values. However, Ukrain had no effect on the protection provided by diazepam, carbamazepine, diphenylhydantoin and phenobarbital. The combined treatment with Ukrain and anti-epileptic drugs did not cause any signs of toxicity.