EFFECT OF UKRAIN ON THE EFFICACY OF ANTI-EPILEPTIC DRUGS AGAINST MAXIMAL ELECTROSHOCK-INDUCED SEIZURES IN MICE
JAGIEŁŁO-WÓJTOWICZ E.,1* KLEINROK Z.,1 FELDO M.1, CHODKOWSKA A.,1 NOWICKY J.W.2
1) Department of Pharmacology, Medical Academy, Jaczewskiego
8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.
* Author to whom correspondence should be addressed.
Summary: It has been found that Ukrain, given intraperitoneally (i.p.), did not influence the threshold for maximal electroconvulsions in mice. Ukrain in doses of 9.5 and 19 mg/kg significantly enhanced the protective efficacy of valproate, decreasing the ED50 values. However, Ukrain had no effect on the protection provided by diazepam, carbamazepine, diphenylhydantoin and phenobarbital. The combined treatment with Ukrain and anti-epileptic drugs did not cause any signs of toxicity.