MODIFICATION OF ANTINOCICEPTIVE ACTION OF MORPHINE BY UKRAIN IN RODENTS

JAGIEŁŁO-WÓJTOWICZ E.¹*, KLEINROK Z.¹, CHODKOWSKA A.¹, FELDO M.,¹ NOWICKY J.W.²

1) Department of Pharmacology, Medical Academy, Jaczewskiego 8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.

*Author to whom correspondence should be addressed.

Summary: Morphine-induced (0.1 mg/kg s.c.) antinociceptive action was determined in rodents by using the writhing syndrome, hot plate and tail-flick tests. Ukrain given i.p. in doses equivalent to 0.05 and 0.1 LD₅₀ did not affect the reactivity of the mice in the writhing syndrome test. Only in a dose of 0.1 LD₅₀ did Ukrain produce an antinociceptive effect in the hot-plate and tail-flick tests. Ukrain significantly enhanced the antinociceptive effect of morphine in the hot-plate and tail-flick tests. The action of morphine was significantly suppressed by Ukrain in the writhing syndrome test in mice. These results indicated that Ukrain modified the antinociceptive action of morphine.