STUDIES CONCERNING THE EFFECT OF UKRAIN IN VIVO AND IN VITRO

BRÜLLER W.*

Bundesstaatliche Anstalt für Experimentell-Pharmakologische und Balneologische Untersuchungen, Währinger Strasse 13a, 1090 Vienna, Austria.

* Author to whom correspondence should be addressed at: Federal Ministry of Health, Sports and Consumer Protection, Department 111/2 (Toxicology), Radetzkystrasse 2, 1031 Vienna, Austria.

Summary: Ukrain, a reaction product of different alkaloids of Chelidonium majus L. (celandine) with Thio-tepa has been investigated for possible use as an anticancer agent. A possible tumour inhibiting effect on the Ehrlich mouse ascites tumour is now tested in vivo. Moreover, possible changes in the oxygen consumption of mouse ascites tumour cells and a guinea pig liver homogenate are to be determined after the administration of Ukrain in vitro with the aid of an oxygen electrode.