INFLUENCE OF UKRAIN ON DNA, RNA AND PROTEIN SYNTHESIS IN MALIGNANT CELLS

NOWICKY J.W.^1*, HIESMAYR W.¹, NOWICKY W.¹, LIEPINS A.²

1) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.
2) Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

* Author to whom correspondence should be addressed.
** Austrian Patent no. 354644

Summary: ³H labelled thymidine, uridine and leucine were used to evaluate the synthesis of DNA, RNA and proteins in malignant cells and normal cells incubated with Ukrain in different concentrations. Compared with the controls, the inhibiting effects of Ukrain are demonstrated in guinea pig hepatocytes, OIL hepatocytes, human tonsil cells, two murine lymphomas, murine myeloma, Yoshida cells, two HeLa strains, EsB- and EB- (murine) lymphomas, YAC-1, P815 and human WiDr cells. Ukrain inhibits the DNA, RNA and protein synthesis in malignant cell lines at relatively high concentrations and to a small extent in normal cells.