ANTINOCICEPTIVE EFFECT OF TEN DAY ADMINISTRATION OF UKRAIN IN MICE AND INTERACTION OF THE TREATMENT WITH MORPHINE

JAGIEŁŁO-WÓJTOWICZ E.^1*, KLEINROK Z.¹, CHODKOWSKA A.¹, NOWICKY J.W.², PIPER H.¹, KUBIATOWSKI T.¹

1) Department of Pharmacology, Medical Academy, Jaczewskiego 8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.

* Author to whom correspondence should be addressed.

Summary: The present study shows that Ukrain, administered i.p. in doses of 9.5 and 19 mg/kg once daily for 10 days in mice, produced evident antinociceptive action in the writhing syndrome and hotplate tests. Moreover, we found that as a result of 10-day treatment with Ukrain the antinociceptive action of morphine (0.1 mg/kg s.c. administered after the last dose of Ukrain) was significantly decreased. These results and the observed interaction between Ukrain and morphine seem to be contraindications to their combined usage.