INTERACTION BETWEEN UKRAIN AND MORPHINE IN THEIR TEN-DAY TREATMENT IN MICE IN THE WRITHING SYNDROME TEST

JAGIEŁŁO-WÓJTOWICZ E.^1*, KLEINROK Z.¹, NOWICKY J.W.², CHODKOWSKA KUBIATOWSKI T.¹, PIPER H.¹

1) Department of Pharmacology, Medical Academy, Jaczewskiego 8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.

* Author to whom correspondence should be addressed.

Summary: The antinociceptive properties of Ukrain and of morphine in their 10 day treatment in mice were studied by the writhing syndrome test. It was found that the antinociceptive action of Ukrain after 10 days of treatment was similar to that of morphine (0.1 mg/kg s.c.) in the same period. Results indicate that the combined treatment with Ukrain and morphine for 10 days completely reduced their antinociceptive action.