STUDY OF THE ANTITUMOR EFFECT OF UKRAIN: THE ROLE OF MACROPHAGE SECRETION OF α-1-PROTEINASE INHIBITOR

KOROLENKO T.A.¹, KALEDIN V.I.², SVECHNIKOVA I.G.¹, LI X.V.¹, STASHKO J.F.¹, ILNITSKAYA S.I.², NIKOLIN V.P.²

1) Institute of Physiology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.
2) Institute of Cytology and Genetics, Siberian Branch of Academy of Sciences, Novosibirsk, Russia.

Address for correspondence: T.A. Korolenko, Institute of Physiology, Siberian Branch of Russian Academy of Medical Sciences, Timakov Str. 4, Novosibirsk, 630117, Russia.

Summary: The positive antitumor effect of Ukrain was shown following i.m. injection o f a mixture of this drug with Krebs-2 carcinoma cells to CBA mice. The protective effect was suggested to be a result of the influx of macrophages into the site of Ukrain injection. In contrast, contralateral administration of Ukrain had a negative effect, confirming our hypothesis that Ukrain attracts cytolytic macrophages. In the murine HA-1 hepatoma model treated by single or repeated Ukrain injections, a moderate positive effect of Ukrain was related to increased macrophage α-1-proteinase inhibitor (PI) secretion. The role of tumor cells and macrophages in the secretion of PI (the main inhibitor of serine proteinases) during tumor development is discussed.