STUDY OF ACUTE TOXICITY OF UKRAIN IN RATS AFTER INTRAVENOUS INJECTION

KULIK G.I.¹, DENEKA E.R.², TODOR I.N.¹, KARMOZINA L.G.²

1) R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev, Ukraine.
2) Department of Pathology, Teaching Hospital #10, Department of Pathology, Ukrainian State Medical University, Kiev, Ukraine.

Address for correspondence: G.I. Kulik, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 252022 Kiev, Ukraine; or E.R. Deneka, Department of Pathology, Teaching Hospital #10, Department of Pathology, Ukrainian State Medical University, 252035 Kiev, Ukraine. P.O. Box #38.

Summary: The acute toxicity of i.v. Ukrain injection in rats was studied. The interrelation between toxicity (death of animals) and dosage was determined by nonlinear regression method. White blood count (WBC) in peripheral blood, weight of animals, and weight of major organs were determined in animals during all stages of investigation. Morphological studies of toxic changes in 40 different organs of rats were performed on macro- and microscopic levels.