INTERACTION BETWEEN UKRAIN AND NALTREXONE IN THE WRITHING SYNDROME TEST IN MICE
JAGIELLO-WÓJTOWICZ E., KLEINROK Z., GUSTAW K.
Department of Pharmacology, Medical University School, Lublin, Poland.
Address for correspondence: E. Jagiello-Wójtowicz, Department of Pharmacology, Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland.
Summary: The interaction between Ukrain and Naltrexone, a nonselective opioid receptor antagonist, was studied in the 'writhing syndrome' test in mice. Naltrexone (1 mg/kg s. c.) was administered i. p. 30 min before Ukrain (2.375, 4.75, 9.5 and 19 mg/kg). In addition, the antinociceptive properties of Ukrain and Naltrexone in 10-day treatment in mice were studied. The results show that the antinociceptive effect of both single dose and prolonged admnistration of Ukrain is completely antagonized by Naltrexone.