RADIOMODIFICATION EFFECTS OF UKRAIN, A CYTOSTATIC AND IMMUNOMODULATING DRUG, ON INTRACELLULAR GLUCOCORTICOID RECEPTION DURING SHORT-TERM γ-IRRADIATION

LUKSA-LICHTENTHAELER G.L.,¹ LADUTKO E.I.,² NOWICKY J.W.³

1) Institute of Applied Cell Culture, Munich, Germany.
2) Laboratory of Biochemistry, Institute of Radiobiology, Minsk, Republic of Belarus.
3) Ukrainian Anti-Cancer Institute, Vienna, Austria.

Address for correspondence: Luksa-Lichtenthaeler G.L., Institute of Applied Cell Culture, Balan st. 6, Munich, Germany.

Summary: The ability of Ukrain, a cytostatic and immunomodulating semisynthetic compound of thiophosphate-modified alkaloids of Chelidonium majus L., to modify the effects of irradiation on intracellular glucocorticoid reception in female rat liver was evaluated after intraperitoneal administration of the drug at 0.4 mg/kg of body weight. Ukrain caused the normalization of the intracellular glucocorticoid-receptor system, influenced by short-term whole-body y-irradiation of rats with 1 Gy, beginning on the 10th day after administration of the drug. It was found that Ukrain minimized the consequences of irradiation in the endocrine system of the experimental animals.