SERUM CYSTATIN C IN PATIENTS WITH HEMOBLASTOSIS

USOVA Т.А.¹, POTERYAEVA O.N.², POSPELOVA Т.І.³, KOROLENKO T. A.¹

1)  Institute of Physiology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.
2)  Institute of Biochemistry, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.
3)  Novosibirsk Medical Academy, Novosibirsk, Russia.

Address for correspondence: T.A. Usova, Laboratory of Cellular Biochemistry, Institute of Physiology, Russian Academy of Medical Sciences, ul. Timakova 4, 630117 Novosibirsk, Russia.

Summary: Human cystatin C is a natural inhibitor of cysteine proteinases involved in the regulation of activity of endogenous cysteine proteinases (cathepsins B, L, H, S) and extracellular control of cysteine proteinase activities. During tumor progression, human cystatin C plays a role in penetration of normal tissues by malignant cells, and inverse correlation between cystatin C and malignant progression has been shown. Serum cystatin C concentration was measured in patients with hemoblastosis. We observed increasing serum cystatin C con­centration in patients with non-Hodgkin's lymphoma, Hodgkin 's lymphoma and multiple myeloma, which par­tially returned to normal levels after courses of antitumor treatment.